At the time when I was conducting my research there was no known method for taking the guinea pig’s temperature. I demonstrated a technique which is now widely used. Charles Jules Henry Nicole Read Quote
The discovery that I soon made that the guinea pig was also susceptible to infection made it possible for me, from the third year on, to preserve the virus on this animal. Charles Jules Henry Nicole Read Quote
From the practical point of view, the susceptibility to infection of the guinea pig proved to be the most useful step forward. Today, all laboratories use this animal for preserving the virus. Charles Jules Henry Nicole Read Quote
I was less successful in my attempts to effect preventive vaccination against typhus by using the virus and in trying to produce large quantities of serum using large animals. Charles Jules Henry Nicole Read Quote
I demonstrated the characteristics of experimental fever. It appears after an incubation period which is never less than five days. It follows the same pattern as natural fever in man, but is of shorter duration and less pronounced. Charles Jules Henry Nicole Read Quote
The fact that I was fortunate enough to escape contagion, in spite of frequent, sometimes daily contacts with the disease, was because I soon guessed how it spread. Charles Jules Henry Nicole Read Quote
Even if it had not been possible to reproduce the disease in animals and consequently to verify the hypothesis, this simple observation would have been sufficient to demonstrate the way in which the disease was propagated. Charles Jules Henry Nicole Read Quote
I finally demonstrated that typhus infection is not hereditary in the louse. Charles Jules Henry Nicole Read Quote
It did not seem likely that I was destined to undertake research on typhus. Charles Jules Henry Nicole Read Quote
Just as the only reservoir for the typhus virus in nature is provided by man, so the only vector of infection is the louse. The bite of the louse is not virulent immediately after the infecting meal. It becomes so only towards the 7th day following infection. Charles Jules Henry Nicole Read Quote
